Table 1.
Phenotypes and Roles of MDSCs in IBD.
| Colitis Model | Colitis Stage | Cell phenotype | General Function | Published Year | Reference |
|---|---|---|---|---|---|
| T cell transfer/DSS induced | chronic | Human MDSCs: CD14+CD19-HLA-DR-/low
Murine MDSCs: CD11b+Gr-1+ |
Anti-inflammatory | 2008 | (46) |
| DSS induced | chronic | Human M-MDSCs: CD14+ HLA-DR-/low
Human G-MDSCs: CD11b+CD33+HLA-DR- Murine MDSCs: CD11b+Gr-1+ |
Anti-inflammatory | 2015 | (47) |
| T cell transfer induced | chronic | Murine MDSCs: CD31+CD11b+Gr-1+ | Anti-inflammatory | 2008 | (51) |
| DSS induced | acute | Murine MDSCs: CD11b+Gr-1+ | Anti-inflammatory | 2011 | (52) |
| DSS induced | chronic | Murine MDSCs: CD11b+Gr-1+ | Anti-inflammatory | 2011 | (53) |
| TNBS induced | chronic | Murine MDSCs: CD11b+Gr-1+ | Anti-inflammatory | 2013 | (54) |
| T cell transfer induced | chronic | Murine G-MDSCs: CD11b+Gr-1+Ly6G+ | Anti-inflammatory | 2014 | (55) |
| DSS induced | acute | Murine M-MDSCs: CD11b+Ly6C+ | Pro-inflammatory | 2009 | (56) |
| T cell transfer induced | chronic | Murine M-MDSCs: CD115+CD11b+Ly6C+ | Pro-inflammatory | 2012 | (57) |
| T cell transfer induced | chronic | Murine G-MDSCs: CD11b+Ly6G+Ly6Cint | Pro-inflammatory | 2012 | (58) |
| TNBS induced | acute | Human MDSCs: CD14-CD15+CD33+HLA-DR-/low
Murine MDSCs: CD11b+Gr-1+ |
Pro-inflammatory | 2017 | (49) |
| IL10-/-IL17A-/- spontaneous | acute | Murine MDSCs: CD11b+Gr-1+ | Pro-inflammatory | 2020 | (60) |