Table 2.
MDSCs-targeted therapies in IBD.
| Colitis Model | Colitis Stage | Key molecules | Therapeutic Effect | Published Year | Reference |
|---|---|---|---|---|---|
| IL10-/-spontaneous | chronic | Oral administration of Resveratrol | Anti-inflammatory | 2012 | (63) |
| DSS induced | acute | Intraperitoneal injection of Quercetin | Anti-inflammatory | 2020 | (64) |
| DSS induced | acute | Oral administration of Butyrate | Anti-inflammatory | 2021 | (65) |
| DSS induced | acute | Deficiency of Protein tyrosine phosphatase 1b as immune mediator | Anti-inflammatory | 2013 | (66) |
| DSS induced | acute | Knock-in of Glycoprotein130 receptor | Anti-inflammatory | 2016 | (67) |
| DSS induced | acute | Intraperitoneal injection of MSCs expressing IL37b | Anti-inflammatory | 2015 | (68) |
| Pdk1flox/floxCD4-Cre spontaneous | chronic | Intravenous injection of Treg cells | Anti-inflammatory | 2016 | (61) |
| DSS induced | acute | Oral administration of A mTOR kinase inhibitor | Anti-inflammatory | 2019 | (69) |
| DSS induced | acute | Intravenous injection of An inhibitor of enhancer of zeste homolog 2 | Anti-inflammatory | 2019 | (70) |
| IL10-/-spontaneous | chronic | Deficiency of IL17A | Pro-inflammatory | 2020 | (60) |
| DSS induced | acute | Enema administration of Acetylcholine | Anti-inflammatory | 2021 | (71) |
| DSS induced | acute | Intraperitoneal injection of An endothelin-A receptor antagonist | Anti-inflammatory | 2021 | (72) |
| DSS induced | acute | Intraperitoneal injection of A cannabinoid receptor 2 inverse agonist | Anti-inflammatory | 2022 | (73) |
| DSS induced | acute/chronic | Intraperitoneal injection of Atorvastatin (drug) | Anti-inflammatory | 2016 | (74) |
| DSS induced | chronic | Intraperitoneal injection of Sildenafil | Anti-inflammatory | 2017 | (75) |
| T cell transfer induced | chronic | Transfer of MDSCs | Anti-inflammatory | 2008 | (46) |
| DSS induced | acute/chronic | Transfer of MDSCs | Anti-inflammatory | 2011, 2016, 2020, 2013, 2021, 2016 | (52, 61, 64, 66, 72, 74) |
| TNBS induced | chronic | Transfer of MDSCs | Anti-inflammatory | 2013 | (54, 76) |
| TNBS induced | acute | Transfer of MDSCs | Pro-inflammatory | 2017 | (49) |
| DSS induced | acute | Transfer of G-MDSCs-derived exosome | Anti-inflammatory | 2016 | (62) |
| TNBS/DSS induced, T cell transfer induced | acute/chronic | Depletion of MDSCs | Pro-inflammatory | 2017, 2008, 2011, 2019, 2021, 2021, 2007 | (49, 51, 53, 70–72, 77) |