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. 2022 Sep 16;7(38):34098–34108. doi: 10.1021/acsomega.2c03387

Table 3. Forced Degradation Data of Clindamycin.

Condition % Degradation sample Assay (% w/w) in degradation sample Purity index Single point threshold Peak purity
Control sample (unstressed) 1.15 98.8 1.000 0.999 Passed
Acid degradation 1 M; HCl 120 min at @ 80 °C 11.50 86.6 1.000 0.998 Passed
Base degradation 1 M; NaOH 1 min @ 80 °C 16.50 82.5 1.000 0.996 Passed
Peroxide Stress 0.5% H2O2 11.30 85.5 1.0000 0.999 Passed
Thermal Stress @ 80 °C 2 h 13.50 85.6 1.000 0.999 Passed
Photo Stress Fluorescent 1.2 M Lux and UV-200 W h–1 (Sample in ampule) direct exposure 1.29 100.9 1.000 0.999 Passed