Table 5. Method Comparison Analysis Data with USP Method (F and T-test).

			Results (Recovery (%), Precision (%RSD)
Test	Parameter	Acceptance Criteria	CMN
USP Method	n = 6 (6 determinations at 100% specification level)	Recovery at each level should be 98–102%	99.3
			100.2
			99.4
			100.2
			99.6
			100.1
	Mean		99.8
	RSD		0.4
Current Method	n = 6 (6 determinations at 100% specification level)	Recovery at each level should be 98–102%	100.9
			100.2
			100.9
			99.6
			98.9
			100.6
	Mean		100.2
	RSD		0.8
F-test	Degrees of freedom		5
	F-Value		0.8595
	P-Value		0.4361
	F-Critical One tail	F < F criticala	5.0503
T-Test	Degrees of freedom		5
	T-Value		–0.9363
	P-Value One tail		0.196
	T-Critical One tail	T < T criticala	2.015
	P-Value Two tail		0.3921
	T-Critical Two tail	T < T criticala	2.5706

^aIndicates reject null hypothesis, i.e., no statistical significance (differences) observed between the current and USP method.