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. 2022 Sep 15;13:955841. doi: 10.3389/fimmu.2022.955841

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Copyright © 2022 Qin, Wang, Huang, Huang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PRSS23 enhances TAM infiltration by regulating FGF2 expression and secretion. (A) The gene expression correlation between FGF2 and the well-known biomarker genes of TAM/M2 macrophage was analyzed. (B) The gene expression correlation between PRSS23 and the well-known biomarker genes of TAM/M2 macrophage was analyzed. (C, D) PRSS23 and FGF2 was upregulated in M2 macrophages. (E) The TAM-like cells were induced by co-culturing with HGC-27 cells and THP-1 derived macrophages. (F) The well-known biomarkers of TAM/M2 macrophages were greatly upregulated. (G) Both FGF2 and PRSS23 were significantly upregulated in TAM-like cells. (H) Overexpression of FGF2 rescued the inhibitory effect of survival of TAM-like cells by PRSS23 depletion. (I) Overexpression of FGF2 rescued the inhibitory effect of GC cell proliferation by PRSS23 depletion. **p < 0.01, ****p < 0.0001, ns means no significant..