Table 4.

Multivariable analysis of the influence of therapy on the presence of macrophage activation syndrome (MAS), MAS requiring pediatric intensive care unit hospitalization (MAS-PICU), and outcome in 274 patients meeting MIS-C criteria.

Parameter [analyzed value]	MAS N = 274	MAS-PICU N = 59	No-Complete recovery at discharge N = 235
Age [1 y]	1.7 (1.1; 1.3); P = 0.0002	NA	NS
Glucocorticosteroids	3.2 (1.3; 7.7); P = 0.009	NA	NS
Heparin [therapeutic level]	NA	12.5 (2.3–68.0); P = 0.003	NS
Hospitalization time [>Median (10 d)]	2.3 (1.1; 4.9); P = 0.028	NS	NS
Mechanical ventilation	3.6 (0.93; 13.6); P = 0.063	NS	NS
MAS	NA	NA	4.0 (1.4–10.9); P = 0.008
Model summary (accuracy)	OR = 6.6; 79.9%; P < 0.0001 (96.3% non-MAS; 20.3% MAS)	OR = 11.2; 84.8% P = 0.002 (90% non-PICU; 55.6% PICU)	P = 0.010