Table 3. Polynomial Coefficient of Each Parameter Quality of Tablet Mass and Tabletsa.
| component | flow
time |
Carr
index |
hardness |
friability |
disintegrating
time |
drug
release |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| linear | quadratic | linear | quadratic | linear | quadratic | linear | quadratic | linear | quadratic | linear | quadratic | |
| SLS | 9.35 | 9.30 | 26.17 | 26.00 | 9.84 | 9.76 | 0.38 | 0.38 | 5.74 | 5.65 | 84.28 | 85.04 |
| CS | 7.65 | 7.60 | 21.17 | 21.00 | 7.44 | 7.36 | 0.31 | 0.31 | 2.62 | 2.53 | 58.65 | 59.41 |
| SLS–CS | 0.60 | 2.00 | 1.00 | –0.02 | 1.04 | –9.10 | ||||||
a
Polynomial coefficients according to the simplex lattice design with the linear and quadratic system. The tablet formula used contains SLS [%] and CS [%]: TA (0.50:4.00), TB (0.75:3.00), and TC (1.00:2.00).