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. 2022 Sep 29;41:289. doi: 10.1186/s13046-022-02483-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — FOXM1-PROTAC inhibits the expression of GLUT1 and PD-L1. A Detection of PD-L1, GLUT1 in HepG2 cells treated with FIP-1 and FOXM1-PROTAC for 24 h. B Decreasing lactate level in HepG2 cells, treated with FIP-1 and FOXM1-PROTAC for 24 h, was showed by Microplate Reader. C, Seahorse extracellular flux analyzer (SEFA) measurement of ECAR metabolic profile in HepG2 cells treated with FIP-1 and FOXM1-PROTAC for 24 h. D Expression of PD-L1 in HepG2 cells after treating with 2-DG for 24 h. E HepG2 cells treated with FIP-1 and FOXM1-PROTAC for 24 h uptake analysis of 2-NBDG (200 μM) on a Flow cytometer. F Flow cytometer analysis of PD-L1 expression on tumor cell surface before or after FOXM1-PROTACs treatment. G Immunofluorescence of tumor samples, FOXM1 (red single), GLUT1 and PD-L1 (red and green merged), ki-67 (green single) and Cell nuclei was stained (blue)