Table 2.

Patient characteristics on intensive care unit admission according to the empirical antimicrobial treatment strategy used

	Total	Broad-spectrum antimicrobial group	Narrow-spectrum antimicrobial group	p value
	n = 254	n = 159	n = 95
Age	72 (59–80.25)	73 (62–80)	72 (53–82)	0.401
Sex				0.698
Male	143 (56.3%)	88 (55.3%)	55 (57.9%)
Female	111 (43.7%)	71 (44.7%)	40 (42.1%)
Severity on ICU admission
APACHE II on  ICU admission	20 (15–26)	21 (17–27)	17 (13–26)	0.002
SAPS II on ICU admission	43 (29–57)	48 (34–61)	37 (22–50)	< 0.001
Total SOFA score on ICU admission	7 (5–10)	8 (5–11)	5 (4–9)	< 0.001
Admission category
Medical	175 (68.9%)	109 (68.6%)	66 (69.5%)	> 0.999
Surgical	74 (29.1%)	47 (29.6%)	27 (28.4%)	0.887
Trauma	5 (2.0%)	3 (1.9%)	2 (2.1%)	> 0.999
Admission diagnosisa
Respiratory	80 (31.5%)	46 (28.9%)	34 (35.8%)	0.267
Digestive	68 (26.8%)	53 (33.3%)	15 (15.8%)	0.002
Cardiovascular	62 (24.4%)	36 (22.6%)	26 (27.4%)	0.451
Neurological	36 (14.2%)	17 (10.7%)	19 (20.0%)	0.043
Renal genitourinary	30 (11.8%)	17 (10.7%)	13 (13.7%)	0.548
Trauma skin	21 (8.3%)	12 (7.5%)	9 (9.5%)	0.641
Other	26 (10.2%)	16 (10.1%)	10 (10.5%)	> 0.999
Comorbidities (N = 241)
Cardiovascular	58 (24.1%)	38 (25.0%)	20 (22.5%)	0.755
Diabetes mellitus	54 (22.4%)	35 (23.0%)	19 (21.3%)	0.873
Solid tumor	40 (16.6%)	28 (18.4%)	12 (13.5%)	0.372
Renal failure	31 (12.9%)	22 (14.5%)	9 (10.1%)	0.426
Cerebrovascular	31 (12.9%)	24 (15.8%)	7 (7.9%)	0.109
Pulmonary	26 (10.8%)	18 (11.8%)	8 (9.0%)	0.528
Other	18 (7.5%)	15 (9.9%)	3 (3.4%)	0.077

Results are shown as n (%) or median (IQR) where applicable

ICU intensive care unit, APACHE Acute Physiology and Chronic Health Evaluation, SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment

^aPatients could have multiple admission diagnoses