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. 2022 Sep 15;9:990538. doi: 10.3389/fmed.2022.990538

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Copyright © 2022 Chen, Yue, Chen, Tong, Yang and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Kaplan-Meier survival curve of OS in patients with orbital DLBCL stratifed by (A) age at diagnosis, (B) marital status, (C) stage, (D) chemotherapy, and (E) radiation. It was revealed that older age, unmarried status and stage IV were associated with worse OS compared by log-rank test. In (A), 60-75 vs<60 years (p < 0.001); >75 vs. < 60 years (p < 0.001). In (B), Unmarried vs. Married (p < 0.001); Single vs. Married (p = 0.520); Unknown vs. Married (p = 0.221). In (C), stage IV vs. stage I (p = 0.001); stage II vs. stage I (p = 0.919); and stage III vs. stage I (p = 0.853), and unknown vs. stage I (p = 0.089). In (D,E), chemotherapy (p = 0.016) and radiation therapy (p = 0.004) had significantly better OS than those without it.