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. 2022 Sep 15;9:988309. doi: 10.3389/fnut.2022.988309

FIGURE 4.

FIGURE 4

PFIE prevents septic shock and attenuates proinflammatory responses in an LPS-induced endotoxemia mouse model. (A) Mortality was monitored for 7 days after LPS injection in the groups (n = 10): PBS (circle); LPS (triangle); LPS + 10 mg/kg of PFIE (inverted triangle); and LPS + 20 mg/kg of PFIE (diamond). (B–I) Mouse serum samples (n = 5) were collected 12 h after LPS injection. Serum levels of AST (B), ALT (C), and CK (D) measured using an automatic chemical analyzer. (F) Serum levels of nitric oxide (NO) metabolites measured using Griess reagent. The levels of TNF-α (G), IL-1β (H), and IL-6 (I) measured using ELISA. *P < 0.05, **P < 0.01, and #P < 0.001 (Student’s t-test).