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. 2022 Sep 15;13:1007326. doi: 10.3389/fimmu.2022.1007326

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Copyright © 2022 Chen, Chen, Dai, Ma, Chen, Bian and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cluster1 and Cluster2 had different immunotherapy response. (A, B) The proportion of immunotherapy responders and non-responders in Cluster1 and Cluster2 patients; (C) Submap algorithm indicated that the Cluster1 patients are sensitive to both PD-1 and CTLA4 therapy; (D–I) The expression level of DPT, RUNX1T1, PTPRN, LSAMP, FDCSP and COL6A6 in immunotherapy responders and non-responders; (J–K) Sva package was used for data combination and batch effect reduction of GSE51088 and GSE53963.