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. 2022 Sep 15;13:1007326. doi: 10.3389/fimmu.2022.1007326

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Copyright © 2022 Chen, Chen, Dai, Ma, Chen, Bian and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CAFs is associated with the immunotherapy response of OC. (A, B) ssGSEA algorithm was used to quantify the CAFs infiltration in TCGA and GSE cohorts; (C, D) In TCGA, patients with low CAFs infiltration had a lower TIDE score and a higher proportion of immunotherapy responders; (E, F) In the GEO cohort, patients with low CAFs infiltration had a lower TIDE score and a higher proportion of immunotherapy responders; (G) In TCGA, patients in Cluster2 had a higher CAFs infiltration; (H) In the GEO cohort, patients in Cluster2 also had a higher CAFs infiltration; (I) DPT, RUNX1T1, PTPRN, LSAMP, FDCSP and COL6A6 were upregulated in the patients with high CAFs infiltration; (J, K) Immune infiltration analysis of Cluster1 and Cluster2. * = P < 0.05, *** = P < 0.001.