Figure 6.

Protein expression significantly different from normal. (A) Protein expression deviated significantly from normal in protein expression signature (PrSIG)-3 (P<0.05, and log₂ change ≥0.50 log₂). Proteins indicated by red circles are potentially targetable. (B) Relative VEGFR (KDR) (left, potential target for PrSIG-2 to 4, and PrSIG-6 to -9) and PARP1 (right, target for patients in PrSIG-3 to -5) protein expression levels across the nine PrSIG. (C) Twenty-four proteins with universally higher (n=7) or lower (n=17) expression (P<0.05, and log₂ change ≥0.50) compared to that in normal CD34⁺ cells. VIM (indicated by the red box) was most strongly upregulated across the nine PrSIG.