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The interaction between CAR T cells and solid tumor cells is controlled by the IFNγ/ICAM-1 axis. (A) During initial interaction with solid tumor cells, CAR T cells secrete IFNγ which induces the transcription of the adhesion molecule ICAM-1. (B) ICAM-1 expression by solid tumor cells strengthens the adhesion with CAR T cells, resulting in tumor cell killing. Created with BioRender (Biorender.com)
