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. 2022 Sep 15;13:937956. doi: 10.3389/fendo.2022.937956

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Copyright © 2022 Gambari, Grigolo and Grassi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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H₂S release by OSCs derived from Alliaceae and Brassicaceae. The known reactions occurring for H₂S release by polysulfides and isothiocyanates are shown. Among garlic-derived polysulfides, diallyl disulfide (DADS) and diallyl trisulfide (DATS) have been shown to release H₂S by reaction with glutathione (GSH) by polarographic H₂S sensor (154) (147) (148). Among glucosinolates, GRA has been found to release H₂S by amperometric approach (149). Similarly, several isothiocyanates showed H₂S-releasing activity: allyl isothiocyanate (AITC), 4-hydroxybenzyl isothiocyanate (HBITC), benzyl isothiocyanate (BITC), erucin (ER), sulforaphane (SFN) (149) (150). While the mechanism of release is unknown for glucosinolates, the mechanism of release by isothiocyanates is dependent on L-cysteine reaction (155). Moreover, different OSCs have different kinetics of H₂S release.