Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 15;13:937956. doi: 10.3389/fendo.2022.937956

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Gambari, Grigolo and Grassi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

A general model describing the routes of absorption of GRA and SFN and a proposed mechanism of action on bone cells based on H₂S-release. Briefly, upon chewing of plants belonging to Brassica genus, myrosinase (MYR, green) is released and can convert glucoraphanin (GRA) to sulforaphane (SFN) (1). GRA can be adsorbed in the stomach or in the small intestine (2). Microbacterial thioglucosidases (MYR, red) converts GRA to SFN which is further adsorbed in large quantities (3). SFN and GRA are released by circulation in bone tissue where can release H₂S and exert anabolic and anticatabolic properties on bone cells (4). The mechanism by which H₂S can be directly released from GRA has not been clarified yet.