Figure 3.

Photomicrographs of the cryosections of the skin of dogs with atopic dermatitis (AD) showing IBA1 immunoreactive cells (macrophages and dendritic cells) expressing cannabinoid receptor 2 (CB2R) (a–d) and G-protein coupled receptor 55 (GPR55) (e–h) immunoreactivity (IR). The white arrows indicate the Dapi-labeled nuclei of IBA1 positive cells co-expressing CB2R- (c) and GPR55-IR (g). The open arrows indicate some IBA1 negative cells of the dermis which expressed CB2R- (c) and GPR55-IR (g). Bar: 50 μm.