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Semiquantitative evaluation of the density of CB2R, GPR55, TRPV1, and TRPA1 immunoreactivity in different cellular elements of the skin of dogs with atopic dermatitis (AD-dogs).
| Receptors | Mast cells (tryptase) | Macrophages and dendritic cells (IBA1) | T-cells (CD3) | Neutrophils (CAL) |
|---|---|---|---|---|
| CB2R | ++ | +++ | + | NA |
| GPR55 | +++ | ++ | +++ | ++ |
| TRPV1 | ++ | ++ | + | – |
| TRPA1 | ++ | + | ++ | – |
C, cytoplasmic; M, membrane; NA, not applied. Immunoreactive cells were graded as: –, negative; +, faint; ++, moderate; +++, bright.
