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. 2022 Sep 15;13:951459. doi: 10.3389/fimmu.2022.951459

Figure 2.

Figure 2

Identification of mutation characteristics and the expression of checkpoints in the different AME subtypes. (A) Waterfall plot of the top 12 recurrently mutated genes in LIHC, which was calculated by MutSig2CV. (B) The mutation number of the 12 genes in each subtype. The size of the circle represents the proportion of mutated tumors in all LIHC tumors, and the distance of the gene to a subtype on a corner represents the proportion of mutated tumors in that subtype. (C) Heatmap of the expression of immune checkpoints in the subtypes. ****P < 0.0001) (D) The proportion of PD1+ and PD1- in the subtypes. (E) The proportion of PD-L1+ and PD-L1- in the subtypes. (F) The proportion of the mutation number of TP53 in the subtypes. (G) The proportion of the mutation number of CTNNB1 in the subtypes.