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. 2022 Sep 15;13:951459. doi: 10.3389/fimmu.2022.951459

Figure 5.

Figure 5

Identification of the function and the mechanism of CTNNB1 in the AME1 subtype. (A) Boxplots of the expression of immune checkpoints in the CTNNB1-Mutation group and CTNNB1-Wild type group in TCGA LIHC samples. (B) Boxplots of the expression of immune checkpoints in the CTNNB1-Mutation group and CTNNB1-Wild type group in the GSE9829 dataset (*P < 0.05; **P < 0.01; ***P < 0.001). (C) Spearman’s correlation of immune checkpoints and the 11 aging-related genes. (D) Spearman’s correlation of PD-L1 and the 11 aging-related genes. (E) Spearman’s correlation of PD1 and the 11 aging-related genes. (F) Spearman’s correlation of PD1 and CCL19 in the CTNNB1 mutation and CTNNB1 wild type samples. (G) Spearman’s correlation of PD-L1 and CCL19 in the CTNNB1 mutation and CTNNB1 wild type samples. (H) Spearman’s correlation of PD-L1 and CD8+ T cells in the CTNNB1 mutation and CTNNB1 wild type samples. (I) Boxplots of the expression of CCL19 in the CTNNB1-Mutation group and CTNNB1-Wild type group in TCGA LIHC samples. (J) Boxplots of the expression of CCL19 in the CTNNB1-Mutation group and CTNNB1-Wild type group in the GSE9829 dataset. (K) qPCR analysis of the expression of CCL19 in the CTNNB1 wild-type HepG2 cells and CTNNB1 mutant Huh6 and SNU398 cells.