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. 2022 May 5;106(10):1940–1951. doi: 10.1097/TP.0000000000004153

FIGURE 1.

FIGURE 1.

The hosts’ plasma torque teno virus (TTV) load in relation to the risk of allograft rejection and infection in kidney (KTX) and lung transplant (LuTX) recipients. A high TTV load indicates a risk of infection, and a low TTV load indicates a risk of rejection. Proposed cutoff values for risk stratification have been converted to values that correspond to the commercial polymerase chain reaction (PCR) to facilitate comparison of the published data. The risk for infection increases above 6.6 log10 c/mL for both KTX and LuTX recipients. For KTX patients, the risk for rejection increases at TTV loads below 4.6 log10 c/mL. The field including an asterisk represents TTV loads below 5.6 log10 c/mL, which already indicate a risk in the LuTX setting due to the higher level of immunosuppression needed to prevent rejection compared with KTX. In KTX recipients transplanted >1 y ago, a TTV load above 3.6 log10 c/mL might indicate sufficient immunosuppression to prevent rejection (double asterisk).