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. 2022 Sep 29;17(9):e0275219. doi: 10.1371/journal.pone.0275219

Fig 4. Correlation between PASI and circRNA/miRNA expression in non-lesional (NL) and lesional (L) skin during secukinumab treatment.

Fig 4

(A-D; left) CircPTPRA (A), ciRS-7 (B), miR-4454+miR-7975 (C), and miR-203a-3p (D) log2-transformed expression values plotted against PASI during 84 days of secukinumab treatment. Simple linear regression was used for correlation between log2-transformed normalized counts and PASI. (A-D; right) CircPTPRA (A), ciRS-7 (B), miR-4454+miR-7975 (C), and miR-203a-3p (D) expression in lesional skin during secukinumab treatment and non-lesional skin. Depicted are normalized counts and median expression; n(NL, L D4, L D14, and L D43) = 14, n(L D0) = 13, n(circRNA-L D84) = 12, and n(miRNA-L D84) = 13.