Table 2. Correlation between miRNA expression changes and PASI during 84 days of secukinumab treatment.

miRNA	R	R squared	p-value
miR-223-3p	0.5241	0.2747	<0.0001
miR-4454+ miR-7975	0.5176	0.2679	<0.0001
miR-106a-5p+ miR-17-5p	0.2833	0.2691	<0.0001
miR-15a-5p	0.4828	0.2331	<0.0001
miR-203a-3p	0.4785	0.2290	<0.0001
miR-132-3p	0.3685	0.1358	0.0020
miR-130a-3p	0.3568	0.1273	0.0028
miR-425-5p	0.3541	0.1254	0.0031
miR-200b-3p	0.3538	0.1252	0.0031
miR-93-5p	0.3038	0.0923	0.0118
miR-221-3p	0.9022	0.0814	0.0184
miR-22-3p	0.2202	0.0485	0.0711
miR-324-5p	0.1970	0.0388	0.1073
miR-146a-5p	0.1819	0.0331	0.1378
miR-455-3p	0.1446	0.0209	0.2390
miR-764	- 0.3561	0.1628	0.0006
miR-301b-3p	- 0.4681	0.2191	<0.0001
miR-412-3p	- 0.4618	0.2133	<0.0001
miR-144-3p	- 0.4570	0.2112	<0.0001

Only significantly deregulated miRNAs with a fold change higher than 2 in lesional relative to non-lesional skin before treatment and normalization of expression upon treatment at day 84 are shown.