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. 2022 Sep 20;119(39):e2117988119. doi: 10.1073/pnas.2117988119

Fig. 2.

Fig. 2.

TGFB2-AS1 suppresses breast cancer tumorigenesis and lung metastases in vivo. (A–E) LM2-AS1 cells and the LM2-EV cells were transplanted orthotopically into mammary fat pad of female NOD/SCID mice, and tumor growth (A), tumor weight (B), tumor morphology (C), BLI images of lung metastasis (D), and its quantitative data (E) at 68 d after orthotopic injection are shown. n = 8 or 10 per group. (F–J) MDA-231 cells with TGFB2-AS1 knockdown by shAS1#1 or shAS1#2 and their control cells (shNC) were transplanted orthotopically into mammary fat pad of female NOD/SCID mice, and tumor growth (F), tumor weight (G), tumor morphology (H), and BLI image of lung metastasis (I) and its quantitative data (J) at 52 d after orthotopic injection are shown (n = 6 per group). Data are presented as means ± SEM (n = 6 to 10). Statistical significance was assessed using two-tailed Student’s t test. *P < 0.05. **P < 0.01.