Table 4.

Univariable and Multivariable Analysis of Determinants of TP-DNA Detection in one or more Sample types in MSM With Early Syphilis, Amsterdam, The Netherlands, November 2018 to December 2019

	TP-DNA Detected ≥ 1 Sample Type	Univariable Model			Multivariable Model
	n/N (%)a	OR	95% CI	P-Value	aOR	95% CI	P-Value
Syphilis stage
Primary	35/70 (50%)	Ref		<.001	Ref		<.001
Secondary	62/73 (85%)	5.64	2.55–12.47		6.83	2.94–15.90
Early latent	29/86 (34%)	0.51	.27–.97		0.55	.27–1.12
Age, median [IQR]b	38 [31–48]	0.81	.03–1.36	.084	0.86	.65–1.14	.304
Age
<35 y	48/76 (63%)	Ref		.140
35–44 y	37/67 (55%)	0.72	.37–1.41
≥45 y	41/86 (48%)	0.53	.28–1.00
Country of birthc
The Netherlands	74/133 (56%)	Ref		.770	Ref		.246
Other	51/95 (54%)	0.92	.54–1.57		0.68	.36–1.31
No. of sex partners, median [IQR] d	6 [4–15]	0.65	.47–.89	.008	0.69	.48–1.00	.046
No. of sex partners
<5	39/58 (67%)	Ref		.105
5–9	32/57 (56%)	0.62	.29–1.33
10–14	19/36 (53%)	0.54	.23–1.28
≥15	33/72 (46%)	0.41	.20–.85
HIV status
Negative	88/145 (61%)	Ref		.024	Ref		.041
Positive	38/84 (45%)	0.54	.31–.92		0.50	.25–.98
Any C. trachomatis infection
No	120/220 (55%)	Ref		.468	Ref		.657
Yes	6/9 (67%)	1.67	.41–6.83		1.46	.27–7.85
Any N. gonorrhoeae infection
No	118/215 (55%)	Ref		.869	Ref		.433
Yes	8/14 (57%)	1.09	.37–3.27		0.59	.16–2.19

Abbreviations: aOR, adjusted odds ratio; CI, confidence interval; HIV, human immunodeficiency virus; IQR, interquartile range ; MSM, men who have sex with men; No., number; OR, odds ratio; Ref, reference; TP-DNA, Treponema pallidum DNA.

Unless otherwise indicated.

OR per 10 year increase in age.

1 missing.

Odds ratio (OR) for each (log + 1) increase in number of partners.