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. 2022 Feb 4;75(6):1037–1045. doi: 10.1093/cid/ciac001

Figure 4.

Figure 4.

Simulations (n = 500 on a built data set of 54 simulated patients) showing the distribution of Cmax and AUC0-∞ of INH, with respect to the dosing regimen and the NAT2 genotype. Dotted black lines represent the target (Cmax between 3 and 6 mg/L and AUC0-∞ above 10.52 mg h/L). The exact dose explored the median WHO recommended dosing regimen at 10 mg/kg. Flat dose explored the revised 2020 Western Cape government tuberculosis drug dosing chart, using 3 weight-bands and dose, 2–2.9 kg infants treated with 25 mg, 3–3.9 kg infants treated with 37.5 mg, 4–7.9 kg infants treated with 50 mg. We explored the model-informed dose that allowed to attain the AUC target for all infants. Abbreviations: AUC, area under the curve; INH, isoniazid; NAT2, N-acetyl transferase 2.