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. 2022 Sep 29;17:113. doi: 10.1186/s13020-022-00666-9

Table 3.

Cell models and interventions of MEPs in the treatment of dyslipidemia

No MEPs Intervention Cell model Concentration Duration References
1 Chrysanthemi flos Extract HUVECs 50, 100 and 200 μg/mL 24 h [51]
2 Citri sarcodactylis fructus Extract 3T3-L1 cells 0.85 and 0.56 mg/ml 5 days [60]
Extract and main components HepG2 and Caco-2 Cells 50 and 100 µg/mL 24 h [61]
3 Crataegi fructus Extract 3T3-L1 cells 50, 100, and 200 ug/mL 24 h [72]
Vitexin 3T3-L1 cells 10 and 50 µM 8 days [79]
4 Gardeniae fructus Geniposide HepG2 0, 65, 130, 260, 390 and 520 μmol/L 24 h [88]
Geniposide HepG2 cells and Caco2 cells 100 μM 12 and 24 h [89]
Geniposide RAW264.7 macrophage cells 2.5, 5, 10, 20, 40 and 80 μM 24 h [90]
Geniposide RAW264.7 macrophage cells 50, 100, and 200 μg/ml 24 h [91]
Genipin Primary hepatocytes 20 μM 24 h [94]
5 Hippophae fructus Flavonoids HL7702 cells 5, 10, 20, 40 and 80 μg/mL 24 h [102]
Kaempferol and kaempferide HepG2 Cells 5, 10 and 20 μM 48 h [103]
6 Mori fructus Extract 3T3-L1 cells 10, 50, 100, and 500 ng/mL 7 days [111]
7 Mori folium Flavonoids L6 skeletal muscle cells 5, 10, 20, 40 and 80 µg/ml 24 h [124]
Flavonoids HepG2 cells 1, 5, 10, 30, 60, 90, 150, and 180 μmol /L 24 h [125]
Extract HepG2 cells 2 mg/mL 24 h [127]
Polysaccharides HepG2 cells 25, 50, 100, 150 and 200 μg/mL 24 h [128]
8 Nelumbinis folium Nuciferine Caco-2 and HT-29 cells 0, 25, 50, 100 and 200 μM 24 h [136]
Nuciferine 3T3-L1 preadipocytes 0, 2.5, 5, 10 and 20 μM 24, 48, 72, 96 and 120 h [138]
Nuciferine THP-1 cells 5, 10 and 20 μmol/L 24 h [139]
Nuciferine THP-1 cells 2.5, 5, 10, and 20 μmol/L 24 h [140]
9 Dioscoreae rhizoma Diosgenin C2C12 cells 0, 20, 40 and 80 μM 3 h [162]
10 Astragali radix Total flavones HepG2 cells 0, 2.5, 5, 10, 20 and 40 μg/ml 24 h [182]
Total flavones HUVECs, RAW264.7, THP-1 cells and peritoneal macrophages 6, 12 and 24 μg/ml 12 h [183]
Astragaloside iv HepG2 cells 50, 100, and 200 μg/mL 24 h [185]
11 Puerariae radix Extract C2C12 cells 0.2 and 0.5 mg/mL 24 h [193]
Puerarin HepG2 cells 75 and 150 μM 24 h [194]
12 Canavaliae semen Extract 3T3-L1 cells 100, 200, 400, and 1000 μg/mL 48 h [212]
13 Persicae semen Amygdalin bone marrow-derived macrophages 25, 50, 100, 200, 400, and 800 μg/ml 24 h [226]
Peach kernel oil HUVECs and RAW264.7 macrophage cells 0.01, 0.05, 0.1, 0.15, and 0.2 μg/mL; 50, 100 and 200 µg/mL 24 h [228]