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. 2022 Sep 15;13:966046. doi: 10.3389/fphys.2022.966046

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Copyright © 2022 Dasí, Roy, Sachetto, Camps, Bueno-Orovio and Rodriguez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Simulated action potential traces for human atrial cardiomyocyte models in the population before (grey) and after (green) experimental calibration. (B–E) Comparison of the electrical restitution between a representative cardiomyocyte model characterized by steep action potential duration restitution (APDR) alone (blue) and additional steep conduction velocity restitution (CVR, pink). (B) Dynamic APDR plotted against the cycle length, showing transient alternation, and (C) against the diastolic interval. (D) CVR. (E) Standard S1S2 APDR. (F) Ionic density distribution (color-code as per panel (A). Data analyzed using Wilcoxon test. *p < 0.05, **p < 0.01, ***p < 0.001.