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. 2022 Sep 15;13:966046. doi: 10.3389/fphys.2022.966046

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Copyright © 2022 Dasí, Roy, Sachetto, Camps, Bueno-Orovio and Rodriguez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison between atrial cardiomyocyte models favoring sustained vs un-sustained fibrillation in homogeneous whole-atria models. (A) Ionic density distribution. (B) Effective refractory period (ERP). (C) Dynamic action potential duration (APD) restitution (as in Figure 3C). Number (N) of models able to propagate all stimuli. (D) Normalized fast Na⁺ current (I_Na) peak and normalized product of I_Na inactivation gates. Data are expressed as medians and IQR and analyzed using Wilcoxon Test. *p < 0.05, **p < 0.01, ***p < 0.001.