FIGURE 5.

(A) Comparison between the cardioversion efficacy (Eff.) obtained in-silico (color bars) in whole-atria models with homogeneous (Homo.) and heterogeneous (Hete.) electrophysiology (EP) and human clinical trials (black bars). Drugs are grouped according to the ionic channels they target. A threshold of 25% block at therapeutic plasma concentration has been considered to denote ion current block. The arrows point towards greater ionic density block. (B) Percentage (%) of APD₉₀ variation after drug modeling or administration with respect to control conditions, in-silico (color bars) and in-vitro (black bars, error bars in-vitro not available, see Supplementary Table S3). The animal silhouettes represent the species analyzed in-vitro.