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. 2022 Sep 15;13:966046. doi: 10.3389/fphys.2022.966046

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Copyright © 2022 Dasí, Roy, Sachetto, Camps, Bueno-Orovio and Rodriguez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Comparison of the ionic density distribution between atrial cardiomyocyte models showing favorable response only to dronedarone, flecainide or vernakalant. (B) Effect of the three antiarrhythmic drugs on the effective refractory period (ERP), stratifying the atrial cardiomyocyte models according to the pharmacological treatment that produced successful cardioversion. Colors on the bars as in (A). Data are expressed as medians and IQR and analyzed using Wilcoxon Test. *p < 0.1, **p < 0.05, ***p < 0.01. ****p < 0.001.