Fig. 5.

TBSS results of the diffusion descriptors that showed statistically significant differences in patients with persistent headache after COVID-19 resolution (COV) compared to healthy controls (HC). COV patients presented lower fractional anisotropy (FA) and higher radial diffusivity (RD) values than HC. White matter skeleton is shown in blue for the RD comparison, and in green for the FA comparison. Voxels with statistically significant differences are shown in red-yellow for the RD comparison (higher values in COV), and in blue for the FA comparison (lower values in COV) considering the assessment without adding sex as a covariate. The color bar shows the 1-p values (family-wise error corrected). At the bottom, the regions of interest (ROIs) with FA or RD significant differences are shown