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. 2022 Aug 27;36(10):2509–2518. doi: 10.1038/s41375-022-01674-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Heatmap visualizing the differentially expressed genes (DEG) identified in WT, Zrsr2^m/m, Tet2^−/−, and Zrsr2^m/mTet2^−/− LSK cells from 3-months-old mice (red, up-regulated genes; blue, down-regulated genes). n = 4-6 replicates/genotype. b Gene expression levels of CLP, PreGM, and PreMegE and MkP associated genes. c KEGG enrichment analysis of DEG in LSK from WT vs Zrsr2^m/mTet2^−/− mice.