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. 2022 Aug 25;36(10):2351–2367. doi: 10.1038/s41375-022-01666-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Algorithm for the treatment of NPM1-mutated AML patients older than 60 years. ^Based on the presence or absence of FLT3 mutations. CR complete remission, FLT3i FLT3 inhibitors, HMA hypomethylating agents, LDAC low-dose cytarabine, allo-HSCT allogeneic hematopoietic stem cell transplantation. B Examples of preemptive therapy with venetoclax as bridging to allo-HSCT. All three patients achieved molecular CR (negativity for NPM1 mutant transcripts) before allo-HSCT. VTX venetoclax, 5-AZA 5-azacytidine, CHT chemotherapy.