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. 2022 Aug 25;36(10):2351–2367. doi: 10.1038/s41375-022-01666-2

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Fig. 5 — The rationale of CD123/CD33 dual targeting trans-signaling strategy is to induce a full cell activation against only CD123/CD33+ leukemic cells while reducing cell stimulation against CD33+ HSPCs and CD123+ endothelial cells [144].