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. 2022 Aug 9;36(10):2384–2395. doi: 10.1038/s41375-022-01662-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Cox regression analysis of IRPR score across 33 cancer types, where p-values are adjusted with Benjamini and Hochberg method for multiple testing. Red color indicates positive association (HR>1) and blue color negative association (HR < 1). B Radar chart of the Spearman correlation between IPRP score and expression of CD47, CTLA4, CD274, and TMB level. The outer side represents a positive correlation, and the inner side represents a negative correlation. The colors mark the immunotherapy targets and the asterisks indicate the statistical significance (p < 0.05, Spearman correlation). C Tumor microenvironment (TME) and immune infiltration (ssGSEA) analysis, where x indicates no significant association (p > 0.05). Statistical significance was assessed with Wald’s test for Hazard ratio for patient prognosis, Spearman correlation for immune-related scoring, and permutation test for ROC-AUC values. ACC Adrenocortical Carcinoma, BLCA Bladder Urothelial Carcinoma, BRCA Breast Invasive Carcinoma, CESC Cervical Squamous Cell carcinoma and Endocervical Adenocarcinoma, CHOL Cholangiocarcinoma, COAD Colon Adenocarcinoma, DLBC Lymphoid Neoplasm Diffuse Large B-cell Lymphoma, ESCA Esophageal Carcinoma, GBM Glioblastoma Multiforme, HNSC Head and Neck Squamous Cell Carcinoma, KICH Kidney Chromophobe, KIRC Kidney Renal Clear Cell Carcinoma, KIRP Kidney Renal Papillary Cell Carcinoma, LAML Acute Myeloid Leukemia, LGG Brain Lower Grade Glioma, LIHC Liver Hepatocellular Carcinoma, LUAD Lung Adenocarcinoma, LUSC Lung Squamous Cell Carcinoma, MESO Mesothelioma, OV Ovarian Serous Cystadenocarcinoma, PAAD Pancreatic Adenocarcinoma, PCPG Pheochromocytoma and Paraganglioma, PRAD Prostate Adenocarcinoma, READ Rectum Adenocarcinoma, SARC Sarcomav, SKCM Skin Cutaneous Melanoma, STAD Stomach Adenocarcinoma, TGCT Testicular Germ Cell Tumors, THCA Thyroid Carcinoma, THYM Thymoma, UCEC Uterine Corpus Endometrial Carcinoma, UCS Uterine Carcinosarcoma, UVM Uveal Melanoma.