Fig. 3. IRF-1 expression is required in hematopoietic cells during C. rodentium infection.

a, b Chimeric mice were generated by reconstitution of irradiated C57BL/6 mice with Irf1^+/+ or Irf1^–/– bone marrow. 8 weeks later, chimeras were infected with C. rodentium and analyzed 9 dpi. a Weights are shown as percentage of baseline (Irf1^+/+ BM: n = 13, Irf1^–/– BM: n = 11). b C. rodentium dissemination to livers, spleens and mLNs. (Irf1^+/+ BM: n = 10, Irf1^–/– BM: n = 5). c Irf1^–/–, Irf1^ΔTie2 and Irf1^ΔIEC mice were infected with C. rodentium and compared to Irf1^fl/fl mice. (Irf1^ΔTie2: n = 12, Irf1^ΔIEC: n = 8, Irf1^fl/fl: n = 18, Irf1^–/–: n = 5) d Tie2^Cre+Irf1^fl/fl mice were infected and compared to Tie2^Cre+Irf1^fl/wt control mice (Tie2^Cre+Irf1^fl/fl: n = 6, Tie2^Cre+Irf1^fl/wt: n = 5). Data is expressed as mean ± SEM. Exact p values defined by two-tailed Mann–Whitney U test (a, b, d) or by one-way ANOVA (Kruskal Wallis test) with Dunnett’s multiple comparisons test (c). Source data are provided as a Source data file.