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. 2022 Sep 29;12:16324. doi: 10.1038/s41598-022-20129-3

Table 1.

Demographic characteristics of the study sample.

PLE-0 (N = 41) PLE-1 (N = 19) PLE-2 (N = 26) Statistics
Demographic
Age (SE) 17.22 (0.11) 17.37 (0.19) 17.31 (0.17) F = 0.25; p = 0.78
Sex, % male 46.3 42.11 53.84 χ2 = 0.66; p = 0.72
Handedness, % right-handed 97.56 94.74 96.15 χ2 = 0.851; p = 0.85
Substance use (12 m)
Cannabis use level (SE) 0.87 (0.21) 1.5 (0.41) 1.3 (0.18) F = 1.18; p = 0.313
Alcohol use level (SE) 2 (0.16) 2.61* (0.20) 1.56* (0.23) F = 5.68; p = 0.005
Tobacco use level (SE) 0.76 (0.25) 1.39 (0.40) 0.74 (0.36) F = 1.05; p = 0.356
Theory of Mind task results
Second-order mentalizing (SD) 88.25% (6.91) 87.78% (7.75) 88.23% (5.62) F = 0.03; p = 0.97
Non-social reasoning control (SD) 92.59% (8.40) 95.10% (8.87) 95.33% (6.84) F = 1.05; p = 0.35
First-order inference control (SD) 96.76% (9.61) 100% (0) 97.33% (9.23) F = 0.89; p = 0.42
Attention and memory control (SD) 99.43% (1.30) 95.88% (1.94) 95.33% (2.44) F = 1.38; p = 0.26
False positive control (SD) 86.11% (22.71) 91.17% (19.65) 82% (28.43) F = 0.74; p = 0.48

SE = Standard Error; SD = Standard Deviation; Substance use rated on a 6-point scale; The theory of mind task looked at stories of false belief which served as a measure of second-order mentalizing, control items tested non-social reasoning, first-order inference, questions to control for attention and memory effect, and items to control for false-positives. Mean percentage of correct answers in each category.

PLE-0 = control trajectory; PLE-1 = decreasing trajectory; PLE-2 = increasing trajectory.

*Significant difference.