Table 1.

Properties and functions of gasdermin family proteins.

Human gene	Alises	Mouse gene	Domaina	Pore-forming activity	RNA expression patternb	Activation mechanism	Disease
GSDMA	GSDM, GSDM1, FKSG9, gasdermin A	Gsdma1-3	N+C	Yes	skin of abdomen, placenta, gastric mucosa, smooth muscle tissue, appendix, gallbladder, duodenum, lymph node, rectum, urinary bladder	Unknown	Alopecia, asthma
GSDMB	GSDML, PRO2521, PP4052, gasdermin B, GSDMB-1	Absent	N+C	Yes	rectum, right lobe of liver, duodenum, cerebellar hemisphere, jejunal mucosa, body of stomach, right uterine tube, gallbladder, spleen, body of pancreas	GZMA	Asthma and other autoimmune diseases
GSDMC	MLZE, gasdermin C	Gsdmc1-4	N+C	Yes	zone of skin, skin of abdomen, spleen, vagina, skeletal muscle tissue, minor salivary gland, gastrocnemius muscle, left ventricle, thymus, urinary bladder	Caspase-8	Breast cancer
GSDMD	DF5L, DFNA5L, GSDMDC1, FKSG10, gasdermin D	Gsdmd	N+C	Yes	spleen, right lobe of liver, duodenum, blood, right lobe of thyroid gland, upper lobe of left lung, right lung, appendix, lymph node, canal of the cervix	Caspase-1/4/511	Sepsis
DFNA5	GSDME, ICERE-1, deafness associated tumor suppressor, gasdermin E	Dfna5	N+C	Yes	germinal epithelium, jejunal mucosa, stromal cell of endometrium, endothelial cell, optic nerve, placenta, oocyte, secondary oocyte, middle temporal gyrus, spinal cord	Caspase-3	Deafness
DFNB59	pejvakin, PJVK, deafness, autosomal recessive 59	Dfnb59	N	Unknown	sperm, anterior pituitary, right lobe of liver, brodmann area 9, left lobe of thyroid gland, gastric mucosa, right uterine tube, canal of the cervix, right lobe of thyroid gland, tibial nerve	Unknown	Deafness

^aN and C stand for gasdermin-N and gasdermin-C, respectively.

^bExpression data taken from [95-99, 104-122] as well as from Bgee (www.bgee.org.com).