Table 1.
Top 10 differentially expressed genes in each cell population compared to all other cell types in the DRG (fold change threshold >1.5)
| Human | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Top genes | Connective Tissue | Endothelial | Macrophages | Mesenchymal | Smooth Muscle | nmSC | mySC | SGC | T-cells |
| 1 | SIK2 | LIFR | RBPJ | FTX | PRKG1 | NRXN1 | FMN2 | GPR98 | PARP8 |
| 2 | LMO4 | PTPRM | SLC1A3 | USP53 | MYH11 | ANK3 | CTNNA3 | HMGCS1 | THEMIS |
| 3 | PRDM6 | EMCN | CD163 | SLC22A3 | INPP4B | GPM6B | FUT8 | TTC6 | RASGRP1 |
| 4 | ANKRD62 | ANO2 | TCF12 | ACADL | PIP5K1B | CNKSR3 | DRP2 | CTNND2 | CD2 |
| 5 | BTBD11 | VWF | MRC1 | SLC2A1 | RBPMS | LRRC8B | MAG | TRDN | LCK |
| 6 | GMDS | EGFL7 | SYK | ANKH | DGKG | MYO1E | NCMAP | QRFPR | STAT4 |
| 7 | NET1 | TCF4 | SPTLC2 | GRIK2 | MYO1B | IL34 | CDH7 | RIMS1 | SKAP1 |
| 8 | GALNT12 | MKL2 | LRRK2 | LAMA2 | FAM13C | CADM2 | ANKRD30B | HEY2 | IL7R |
| 9 | FOXC1 | FLT1 | DENND3 | PAMR1 | ABCC9 | KCNMB4 | LRRC7 | SHANK2 | ACAP1 |
| 10 | GLCE | CLDN5 | SLC9A9 | NGFR | LDB3 | ST6GALNAC5 | PMP22 | MMD2 | CD96 |
| Mouse | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Top genes | Connecive Tissue | Endothelial | Macrophages | Mesenchymal | Neurons | Pericytes | Schwann cells | SGC | Smooth Muscle | T-cells |
| 1 | SAA1 | CLDN5 | LY86 | MFAP4 | GAL | KCNJ8 | NCMAP | FABP7 | PLN | CAMP |
| 2 | SAA2 | LY6C1 | PF4 | SFRP4 | TAC1 | ACE2 | SLC36A2 | BCAN | FBXL22 | NGP |
| 3 | CDKN2A | SOX17 | CCL12 | SLC47A1 | PRPH | ADRA2A | FAM178B | RP24-247B20.1 | TCF15 | S100A8 |
| 4 | OSR2 | GPIHBP1 | BCL2A1B | COMP | ELAVL4 | ABCC9 | CLDN19 | MMD2 | ACTA2 | S100A9 |
| 5 | LUM | SLCO1A4 | C1QC | SLC4A10 | SCG2 | COLEC11 | MLIP | ACSBG1 | MYH11 | LTF |
| 6 | A2M | GRRP1 | CCL4 | H19 | STMN2 | TRPC6 | PRX | LRRTM1 | KCNA5 | 1100001G20RIK |
| 7 | CCL11 | PLVAP | CD74 | IGF2 | RPRM | KCNE4 | PMP2 | DHRS2 | TAGLN | RETNLG |
| 8 | APOD | FLT1 | C1QA | PROK2 | TRPV1 | RGS5 | KCNK1 | TEX40 | MAP3K7CL | LCN2 |
| 9 | 6030408B16RIK | RBP7 | MS4A6C | DIO2 | EEF1A2 | AGTR1A | IL17B | GM2115 | TESC | LY6G |
| 10 | CDKN2B | ELTD1 | CTSS | NOV | ISL1 | PLA1A | OTOP1 | LECT1 | NTF3 | MMP8 |
| Rat | ||||||||
|---|---|---|---|---|---|---|---|---|
| Top genes | Connective Tissue | Endothelial | Macrophage | Mesenchymal | Neuron | Pericytes | Schwann cell | SGC |
| 1 | SCARA5 | CLDN5 | C1QA | CLDN11 | ADCYAP1 | KCNJ8 | MAG | TYRP1 |
| 2 | POSTN | FLT1 | LYZ2 | KCNJ13 | SCG2 | RGS5 | SLC36A2 | IGFBP2 |
| 3 | CRISPLD2 | CYYR1 | C1QC | GZMM | SNHG11 | ACTA2 | CLDN19 | CSN1S1 |
| 4 | LOC100911545 | SLCO14A | C1QB | SLC16A11 | CALCB | NDUFA4L2 | NCMAP | SCRG1 |
| 5 | DNAH11 | FAM110D | TYROBP | ALDH1A3 | NTRK1 | CCL19 | SYCE3 | SPP1 |
| 6 | RBP4 | ABCG2 | AIF1 | IGFBP6 | RIT2 | HIGD1B | KCNK1 | CDH15 |
| 7 | GAD1 | SOX17 | FCER1G | CPXM2 | PCBD1 | NPY1R | BCAS1 | FABP7 |
| 8 | MYOC | PROM1 | CCL4 | KLF5 | SYT1 | RASL11A | PRX | SCD |
| 9 | SRPX | ADGRL4 | CXCL2 | GJB2 | LAMP5 | INPP4B | KCNA1 | FBLN5 |
| 10 | MEOX1 | PLVAP | CCL6 | TBATA | NSG2 | ADRA2A | MME | LOC102553138 |