Table 1.
Putative cholesterol binding proteins of Plasmodium falciparum.
| Protein | Gene ID (Previous Gene ID) | Expression (a) | Conserved (b) | Essential (c) | Phenotype of mutant (d) | |
|---|---|---|---|---|---|---|
| Fam A | PF3D7_1463500 (PF14_0607) | unknown | All Plasmodium | No (asexual) | ND | (Frech and Chen, 2011; Fougère et al., 2016) |
| NCR1 | PF3D7_0107500 (PFA0375c) | liver stage, asexual (trophozoite, schizont), very low gametocytes, ookinetes, sporozoites | All Plasmodium | Yes (asexual) | lethal | (Istvan et al., 2019) |
| ABCG2 | PF3D7_1426500 (PF14_0244) | female gametocytes (low expression male) | All Plasmodium | No (asexual) | Decreased cholesteryl esters, diacylglycerols and triacylglycerols in gametocytes | (Tran et al., 2014) |
| Oxysterol binding protein (putative) | PF3D7_1131800 (PF11_0327) | liver stage, asexual stage (trophozoite, schizont), gametocytes (male, female), ookinete | All Plasmodium | No (asexual) | ND | |
| Phosphatidylcholine-sterol acyltransferase, putative | PF3D7_0629300 (PFF1420w) | liver stage, asexual stage (trophzoite, schizont), oocyst, sprozoite (injected) | All Plasmodium | No (asexual) | Delayed egress from PV in liver stage | (Burda et al., 2015) |
| PFA66 | PF3D7_0113700 (PFA0660w) | asexual stage | Laverania | No (asexual) | Malformation of knobs | (Petersen et al., 2016; Diehl et al., 2021) |
Note that in most cases cholesterol binding has not been shown biochemically and is inferred by homology only.
ND, Not determined.