Table 1.
Validation of spectral modelling of overlapping 19F-MRS peaks for c1a and c1b using jMRUI software.
| c1a: c1b | 19F-MRS signal area | 19F-MRS signal ratio c1a:c1b | ||
|---|---|---|---|---|
| mg: mg | c1a | c1b | Observed | Expected |
| 0.4: 0 | 4033 | – | n.a. | n.a. |
| 0.4: 0.1 | 4261 | 1158 | 3.68 | 4 |
| 0.4: 0.2 | 3628 | 2177 | 1.66 | 2 |
| 0.4: 0.4 | 4125 | 4160 | 0.99 | 1 |
The proportions of peak areas of c1a (keto tracer) and c1b (hydroxy metabolite) in blood (4 mL) showed reasonable agreement with the expected ratio. 0.4 mg of c1a in blood was scanned alone and after addition of variable amounts of c1b at near their Limits of Detection (0.1–0.4 mg). Spectra were acquired with 800 repetitions (400 s). Signal areas are in arbitrary units. n.a. = not applicable.