TABLE 1.

Roles of LSD1 in BC progression.

Substrates	Complexes/pathways	Target genes	Functions	References
H3K4me2/me1	—	p57kip2	Promoting BC initiation	Bradley et al. (2007)
H3K4me2/me1	CAC1/LSD1/ERα	ERα-target genes	Inhibiting proliferation	Kim et al. (2013)
H3K9me2/me1	ASXL2/LSD1/UTX/MLL2	ERα	Promoting proliferation	Park et al. (2016)
H3K4me2/1	LSD1/β-catenin	Lefty1	Promoting proliferation	Yakulov et al. (2013)
H3K4me2/1	LSD1/SIN3A/HDAC	CASP7, TGFB2, CDKN1A(p21), HIF1A, TERT, and MDM	Sensitizing BC cells to chemotherapy	Yang et al. (2018d)
H3K4me1/me2	LSD1/HDAC5	p21 and CLDN7	Hindering BC proliferation and invasion	Cao et al. (2017), Cao et al. (2018)
H3K4me2	Snail	E-cadherin, PTEN	Promoting EMT	Lin et al., 2010, Lin et al. (2014)
H3K4me2	Slug	BRCA1, ESR1	Inhibiting invasion	Bai et al., (2017), Phillips and Kuperwasser, (2014)
H3K9me2, H3K4me2	AR	E-cadherin and Vimentin	Promoting progression and metastasis	Feng et al. (2017)
H3K4me2	LSD1/CoREST	IGF1R, RHOA, and TGFB1	Inhibiting metastasis	Wang et al. (2009)
H3K4me2	ZNF516/CtBP/LSD1/CoREST	EGFR	Inhibiting proliferation and metastasis	Li et al. (2017)
H3K4me1/me2	BRMS1/LSD1/CoREST	Vimentin	Suppressing metastasis and invasion	Qiu et al. (2018)
H3K4me1/me2	LSD1/NuRD/SIX3	WNT1 and FOXC2		Zheng et al. (2018)
H3K4me2, H3K4me3	LSD1/NuRD/KDM5B	CCL14		Li et al. (2011)
H3K4me2	LSD1/GATA3	GATA3, TRIM37		Hu et al. (2019)
H3K4me1/me2, H3K9me2	OTUD7B/LSD1	Snail, CDK6, …	Promoting metastasis	Gong et al. (2021)
H3K4me1/me2	PKCα/LSD1	E-cadherin	Promoting EMT and metastasis	Feng et al. (2016)
H3K4me1/me2	PRMT4/LSD1/USP7	E-cadherin and Vimentin	Promoting invasion and metastasis	Liu et al. (2020a)