TABLE 2.
Regulatory roles of LSD1 in BC angiogenesis and microenvironment.
| Substrates | Ligand proteins | Complexes/pathways | Target genes | Functions | References |
|---|---|---|---|---|---|
| HIFαK391 | NuRD | LSD1/NuRD | VEGF | Promoting angiogenesis | Lee et al. (2017) |
| H3K4me2, H3K4me3 | KDM5B and NuRD | KDM5B/LSD1/NuRD | CCL14 | Suppressing angiogenesis | Li et al. (2011) |
| H3K4me2/1 | PKC-θ | LSD1S111/PKC-θ | JUNB, KLF10, KLF6, and CCL2 | Promoting mesenchymal and stem-like signature, and reducing M1 macrophage | Boulding et al. (2018) |
| H3K4me2 | — | — | CCL5, CXCL -9, -10, and PD-L1 | Reducing CD8+ T cell infiltration | Bennani-Baiti, (2012), Shen et al. (2022) |
| H3K4me2, H3K9me2 | CoREST | LSD1/CoREST | Macrophage polarization genes | Inhibiting Mф toward a M1-like phenotype in the TME | Benedetti et al. (2019) |