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. 2022 Sep 16;12:912490. doi: 10.3389/fonc.2022.912490

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Copyright © 2022 Yoshida, Yaegashi, Toriumi, Kadomoto, Iwamoto, Izumi, Kadono, Ikeda and Mizokami

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathological manifestations of prostate re-biopsy. Hematoxylin and eosin staining (magnification, ×200): (A) the tumor tissue is infiltrated with chromatin-rich, naked nucleated tumor cells with an increased nucleus/cytoplasm ratio of irregular nuclear shape. Immunohistochemistry (magnification, ×200): (B) chromogranin A, (C) synaptophysin, (D) CD56, (E) INSM1, (F) SSTR2, and (G) PD-L1 (focal) are positive, and (H) AR and (I) PSA are negative. (J) Ki-67 is also positive with a Ki-67 labeling index over 90%.