Table 1.

Major concerns regarding pediatric patient safety.

Matter of concern	Issues
Physical characteristics	Children's small size, weight, and morphology need a suitable healing environment (5, 6)
Capacity to consent to medical treatment/Legal Status	Cognitive development affects the capacity to choose a medical treatment/ consent to clinical research. The assessment of decision-making capacity in minors is one of the most compelling and debated topics in pediatric healthcare (7–10). The legal status of minors slightly changes between Countries. Normally, caregivers' permission is needed to choose or refuse any kind of treatment (11)
Lack of children-dedicated healthcare facilities	Settings in which patients had the most complex needs imply a high error rate. Children require healthcare focusing on their needs so they must be treated in children's hospitals (12)
Lack of pediatric guidelines	The growing lawsuits against healthcare professionals led the scientific community to great interest in drafting clinical guidelines, which have to be standardized and subjected to quality control in recent years (13, 14)
Lack of labeled medications	Most medications are not labeled for use in the pediatric population (15)