Table 2.
Pathological result of tumor response to neoadjuvant therapy.
| Characteristics | OverallN=184 | pNCTN=92 | TNTN=92 | P value | |
|---|---|---|---|---|---|
| ypT (%) | ypT0 | 40 (21.7) | 16 (17.4) | 24 (26.1) | 0.512 |
| ypT1 | 1 (0.5) | 0 (0.0) | 1 (1.1) | ||
| ypT2 | 24 (13.0) | 12 (13.0) | 12 (13.0) | ||
| ypT3 | 82 (44.6) | 44 (47.8) | 38 (41.3) | ||
| ypT4 | 37 (20.1) | 20 (21.7) | 17 (18.5) | ||
| ypN (%) | ypN0 | 106 (57.6) | 50 (54.3) | 56 (60.9) | 0.112 |
| ypN1 | 43 (23.4) | 19 (20.7) | 24 (26.1) | ||
| ypN2 | 35 (19.0) | 23 (25.0) | 12 (13.0) | ||
| Differentiation (%) | No tumor* | 42 (22.8) | 16 (17.4) | 26 (28.3) | 0.02 |
| Poor | 22 (12.0) | 15 (16.3) | 7 (7.6) | ||
| Moderate | 76 (41.3) | 33 (35.9) | 43 (46.7) | ||
| Well | 44 (23.9) | 28 (30.4) | 16 (17.4) | ||
| TRG (%) | 0 | 39 (21.2) | 15 (16.3) | 24 (26.1) | 0.095 |
| 1 | 13 (7.1) | 4 (4.3) | 9 (9.8) | ||
| 2 | 100 (54.3) | 53 (57.6) | 47 (51.1) | ||
| 3 | 32 (17.4) | 20 (21.7) | 12 (13.0) | ||
| Response (%) | CR* | 38 (20.7) | 15 (16.3) | 23 (25.0) | 0.408 |
| PR | 76 (41.3) | 40 (43.5) | 36 (39.1) | ||
| SD | 60 (32.6) | 33 (35.9) | 27 (29.3) | ||
| PD | 10 (5.4) | 4 (4.3) | 6 (6.5) | ||
| ORR (%) | SD+PD | 70 (38.0) | 37 (40.2) | 24 (26.1) | 0.06 |
| CR+PR | 114 (62.0) | 55 (59.8) | 68 (73.9) | ||
| DCR (%) | PD | 10 (5.4) | 4 (4.3) | 6 (6.5) | 0.745 |
| CR+PR+SD | 174 (94.6) | 88 (95.7) | 86 (93.5) | ||
| pCR (%) | PR+SD+PD | 146 (79.3) | 77 (83.7) | 69 (75.0) | 0.202 |
| CR | 38 (20.7) | 15 (16.3) | 23 (25.0) | ||
pNCT, prolonged neoadjuvant chemotherapy; TNT, total neoadjuvant therapy; ypT, Pathological T stage after neoadjuvant therapy; ypN, Pathological N stage after neoadjuvant therapy; TRG, tumor regression grade; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; ORR, Objective regression rate; DCR, Disease control rate; pCR, Pathological complete regression.
*The number of “No tumor” patients were more than “CR” patients because four patients had complete tumor regression but still had positive lymph nodes.