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. 2022 Sep 16;10:949184. doi: 10.3389/fcell.2022.949184

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Copyright © 2022 Handschuh and Glösmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microscopic dual energy CT (microDECT) for imaging skeletal development. (A) MicroDECT for imaging cartilage and bone in ruthenium red stained E16.5 mouse embryos. The embryo is scanned using two different X-ray spectra (40 kVp, 60 kVp), which allows separating of hydroxyapatite and ruthenium attenuation using material decomposition. Material fractions can be visualized using volume rendering and false colours mimicking the colour of Alizarin red/Alcian blue stained specimens (Figures 3G–I from Gabner et al., 2020, Development 147 (11)). (B) Examples of conventional greyscale microCT visualisation (left) and microDECT visualisation (right) of the developing forelimb and ribcage in a wild type E16.5 mouse embryo [Figures 4E,G,H,J from Gabner et al., 2020, Development 147 (11)]. All images reprinted by permission from the Company of Biologists.