Table 2.
analyses to assess vaccine effectiveness against symptomatic disease and hospitalisation endpoints
| Analysis | Analysis name | Pillar of testing | Cases (test positive) | Controls (test negative) |
|---|---|---|---|---|
| 1 | Symptomatic disease | 2 | Symptomatic infection | Symptomatic infection (same as cases) |
| 2 | ECDS All—all controls | 2 | Symptomatic ECDS admitted | Symptomatic infection |
| 3 | ECDS All—ECDS controls | 2 | Symptomatic ECDS admitted | Symptomatic ECDS admitted (same as cases) |
| 4 | ECDS Respiratory coded—all controls | 2 | Symptomatic ECDS admitted with a Respiratory SNOMED code | Symptomatic infection |
| 5 | ECDS Respiratory coded—ECDS controls | 2 | Symptomatic ECDS admitted with a Respiratory SNOMED code | Symptomatic ECDS admitted with a Respiratory SNOMED code (same as cases) |
| 6 | SUS, 0 days | 1 & 2 | SUS admitted with a Respiratory ICD code with length of stay = 0 | SUS admitted with a Respiratory ICD code with length of stay = 0(same as cases) |
| 7 | SUS, not primary, 1+ days | 1 & 2 | SUS admitted with length of stay ≥1 day and Respiratory ICD code not in the primary field | SUS admitted with length of stay ≥1 day and Respiratory ICD code not in the primary field (same as cases) |
| 8–10 | SUS, primary, stay 1+, 2+, 3+ | 1 & 2 | SUS admitted, primary respiratory ICD code ≥1, ≥2, ≥3 days stay | SUS admitted, primary respiratory ICD code ≥1, ≥2, ≥3 days stay (same as cases) |
| 11 | SUS, primary, stay 2+, O2 | 1 & 2 | SUS admitted, primary respiratory ICD code, ≥2 days stay, oxygen use | SUS admitted, primary respiratory ICD code, ≥2 days stay, oxygen use (same as cases) |
| 12 | SUS, primary, stay 2+, O2/Vent/ICU | 1 & 2 | SUS admitted, Respiratory ICD code primary, ≥2 days stay, oxygen use or ventilation of ICU admission. | SUS admitted, Respiratory ICD code primary, ≥2 days stay, oxygen use or ventilation of ICU admission. (same as cases) |
ECDS Emergency Care Dataset—administrative data from emergency departments, SUS Secondary Users Service—administrative data from all secondary care which is coded on discharge.
Pillar 1 testing: clinical need, health workers and travel.
Pillar 2 testing: wider population testing, including drive/walk in and home testing.